Software implementing ERSA is now available!
Download the most recent version here.
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Questions, comments, bug reports, feature requests?
Contact David Witherspoon
(david.witherspoon@genetics.utah.edu) or Chad Huff (chadhuff@yahoo.com).
Abstract
Accurate estimation of recent shared ancestry is important for genetics, evolution, medicine, conservation biology, and forensics.
Established methods estimate kinship accurately for first- through third-degree relatives. We demonstrate that chromosomal
segments shared by two individuals due to identity by descent (IBD) provide much additional information about shared ancestry.
We developed a maximum-likelihood method for the estimation of recent shared ancestry (ERSA) from the number and lengths of
IBD segments derived from high-density SNP or whole-genome sequence data. We used ERSA to estimate relationships from SNP
genotypes in 169 individuals from three large, well-defined human pedigrees. ERSA is accurate to within one degree of relationship
for 97% of first- through fifth-degree relatives and 80% of sixth- and seventh-degree relatives. We demonstrate that ERSA's
statistical power approaches the maximum theoretical limit imposed by the fact that distant relatives frequently share no
DNA through a common ancestor. ERSA greatly expands the range of relationships that can be estimated from genetic data and is
implemented in a freely available software package.
